Clinical Microbiology Newsletter
Volume 26, Issue 3 , Pages 17-21 , 1 February 2004

Can sepsis be better defined? Contribution of a novel assay for endotoxin

  • Debra M. Foster, B.Sc.

      Affiliations

    • Mailing Address: Debra M. Foster, Spectral Diagnostics Inc., 135 The West Mall, Toronto, Ontario M9A 2C4, Canada. Tel.: 416-626-3233 ext. 226. Fax: 416-626-7383.
    • ,
  • Anastasia Derzko, M.P.H.

References 

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  2. Sibbald WJ, et al.  Sepsis, SIRS and infection. Intensive Care Med. 1995;21:299–301
  3. Vincent JL. Dear SIRS, I'm sorry to say that I don't like you…. Crit. Care Med. 1997;25:372–374
  4. Opal SM, Horn DL. The microbial aspects of sepsis: does the organism and its treatment affect outcome?. Sepsis. 1999;3:51–55
  5. Alberti C, et al.  for the European Sepsis Group  Influence of systemic inflammatory response syndrome and sepsis on outcome of critically ill infected patients. Am. J. Respir. Crit. Care Med. 2003;168:77–84
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  10. Marshall JC, et al.  Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC trial. J. Infect. Dis. 2004; (accepted)
  11. Soong CV. Intramucosal acidosis and systemic host responses in abdominal aortic aneurysm surgery. Crit. Care Med. 1997;25:1472–1479
  12. Corely OA, Schirmacher P. Clinical picture: bacterial translocation in neutropenic sepsis. Lancet. 2001;358:1842
  13. Van Deventer SJH, Ten Cate JW, Tygat GNJ. Intestinal endotoxemia. Clinical significance. Gastroenterology. 1988;94:825–831
  14. Doig CJ, et al.  Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill patients. Am. J. Respir. Crit. Care Med. 1998;158:444–451
  15. Opal SM, et al.  Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock. J. Infect. Dis. 1999;180:1584–1589
  16. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 2003;348:138–150
  17. Lin E, Lowry SF. The human response to endotoxin. Sepsis. 1998;2:255–262
  18. Danner RL, et al.  Endotoxemia in human septic shock. Chest. 1991;99:169–175
  19. Hurley JC. Concordance of endotoxemia with gram-negative bacteremia in patients with gram-negative sepsis: a meta-analysis. J. Clin. Microbiol. 1994;32:2120–2127
  20. Cohen J. The detection and interpretation of endotoxemia. Intensive Care Med. 2000;26:S51–S56
  21. Bates DW, et al.  Limulus amebocyte lysate assay for detection of endotoxin in patients with sepsis syndrome. Clin. Infect. Dis. 1998;27:582–591
  22. Romaschin AD, et al.  A rapid assay of endotoxin in whole blood using autologous neutrophil-dependent chemiluminescence. J. Immunol. Methods. 1998;212:169–185
  23. Marshall JC, et al.  Measurement of endotoxin activity in critically ill patients using whole blood neutrophil chemiluminescence. Crit. Care. 2002;6:342–348
  24. Rivers E, et al.  for the Early Goal Directed Therapy Collaborative Group  Early goal-directed therapy in the treatment of severe sepsis and septic shock. N. Engl. J. Med. 2001;345:1368–1377

PII: S0196-4399(04)90010-4

Clinical Microbiology Newsletter
Volume 26, Issue 3 , Pages 17-21 , 1 February 2004

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