Clinical Microbiology Newsletter
Volume 30, Issue 1 , Pages 5-6 , 1 January 2008

Successful Use of Linezolid in the Treatment of Enterococcal Endocarditis: an Effective and Safe Option?

  • Maria Javaid, M.D.

      Affiliations

    • Division of Cardiology, Department of Medicine, SUNY Upstate Medical University, Syracuse, New York
    • ,
  • Abdelhamed Abdelhamed, M.D.

      Affiliations

    • Division of Cardiology, Department of Medicine, SUNY Upstate Medical University, Syracuse, New York
    • ,
  • Huma Samar, M.D.

      Affiliations

    • Division of Cardiology, Department of Medicine, SUNY Upstate Medical University, Syracuse, New York
    • ,
  • Michael Cynamon, M.D.

      Affiliations

    • Veterans Affairs Medical Center, Syracuse, New York
    • Corresponding Author InformationMailing Address: Michael Cynamon, M.D., Department of Medicine, VAMC, 800 Irving Avenue, Syracuse, NY 13210. Tel.: 315-425-4884. Fax: 315-425-4871

References 

  1. Karchmer AW . Infections of prosthetic heart valves . In:  Waldvogel FA ,  Bisno AL editor. Infections associated with indwelling medical devices . 3rd ed.. Washington, DC: ASM Press; 2000;p. 145–172
  2. Weinstein MP , et al.   The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults . Clin. Infect. Dis. . 1997;24:584–602
  3. Anonymous  . National Nosocomial Infections Surveillance (NNIS) system report, data summary from January 1990 to May 1999 . Am. J. Infect. Control . 1999;27:520–532
  4. Edmond MB , et al.   Nosocomial bloodstream infections in United States hospitals: a three-year analysis . Clin. Infect. Dis. . 1999;29:239–244
  5. Wisplinghoff H , et al.   Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study . Clin. Infect. Dis. . 2004;39:309–317
  6. Gray J , et al.   Enterococcal bacteraemia: a prospective study of 125 episodes . J. Hosp. Infect. . 1994;27:179–186
  7. Maki DG , Agger WA . Enterococcal bacteremia: clinical features, the risk of endocarditis, and management . Medicine . 1988;67:248–269
  8. Murray BE . The life and times of the enterococcus . Clin. Microbiol. Rev. . 1990;3:46–65
  9. Patterson JE , et al.   An analysis of 110 sexrious enterococcal infections. Epidemiology, antibiotic susceptibility, and outcome . Medicine . 1995;74:191–200
  10. Ang JY , et al.   Vancomycin-resistant Enterococcus faecium endocarditis in a premature infant successfully treated with linezolid . Pediatr. Infect. Dis. J. . 2003;22:1101–1103
  11. Babcock HM , et al.   Successful treatment of vancomycin-resistant Enterococcus endocarditis with oral linezolid . Clin. Infect. Dis. . 2002;32:1373–1375
  12. Rao N , White GJ . Successful treatment of Enterococcus faecalis prosthetic valve endocarditis with linezolid . Clin. Infect. Dis. . 2002;35:902–904
  13. Zimmer SM , et al.   Failure of linezolid treatment for enterococcal endocarditis . Clin. Infect. Dis. . 2003;37:e29–e30
  14. Chien JW , et al.   Use of linezolid, an oxazolidinone, in the treatment of multidrug-resistant gram-positive bacterial infections . Clin. Infect. Dis. . 2000;30:146–151

PII: S0196-4399(07)00056-6

doi: 10.1016/j.clinmicnews.2007.12.002

Clinical Microbiology Newsletter
Volume 30, Issue 1 , Pages 5-6 , 1 January 2008

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