Clinical Microbiology Newsletter
Volume 31, Issue 6 , Pages 41-44 , 15 March 2009

Hidden Beta-Lactamases in the Enterobacteriaceae – Dropping the Extra Disks for Detection, Part I

  • Daniel R. Sundin, Ph.D., D(ABMM)

      Affiliations

    • Corresponding Author InformationMailing Address: Daniel R. Sundin, Ph.D., D(ABMM), Department of Laboratories, Spectrum Health, 100 Michigan St. NE, Grand Rapids, MI 49503. Tel.: 616-391-2685. Fax: 616-391-1986

References 

  1. Szabo D , et al.   Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae. . Antimicrob. Agents Chemother . 2006;50:2833–2835
  2. Wu PJ , et al.   Effect of hyperproduction of TEM-1 beta-lactamase on in vitro susceptibility of Escherichia coli to beta-lactam antibiotics . Antimicrob. Agents Chemother . 1994;38:494–498
  3. Bradford P . Extended-spectrum beta-lactamase in the 21st century: characterization, epidemiology, and detection of this important resistance threat . Clin. Microbiol. Rev. . 2001;14:933–951
  4. Livermore D . Beta-lactamases: laboratory and clinical resistance . Clin. Microbiol. Rev. . 1995;8:557–584
  5. Clinical and Laboratory Standards Institute  . In: Performance standards for antimicrobial susceptibility testing; 17th informational supplement. M100-S17 . vol. 27: Wayne, PA: CLSI; 2007; no. 1.
  6. Jarlier V , et al.   Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in enterobacteriaceae: hospital prevalence and susceptibility patterns . Rev. Infect. Dis. . 1988;10:867–878
  7. Coudron P , et al.   Occurrence and detection of extended-spectrum beta-lactamases in members of the family Enterobacteriaceae at a veterans medical center: seek and you may find . J. Clin. Microbiol. . 1997;35:2593–2597
  8. Pfaller M , et al.   Overview of the epidemiological profile and laboratory detection of extended-spectrum beta-lactamases . Clin. Infect. Dis. . 2006;42:S153–S163
  9. Tzelepi E , et al.   Detection of extended-spectrum beta-lactamases in clinical isolates of Enterobacter cloacae and Enterobacter aerogenes. . J. Clin. Microbiol. . 2000;38:542–546
  10. Bonnet R . Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes . Antimicrob. Agents Chemother . 2004;48:1–14

 *Editor's Note: Part II of this article will be published in the April 1, 2009 issue of CMN (Vol. 31, No. 7).This manuscript was scheduled for publication before release of the January 2009 CLSI document entitled “Performance Standards for Antimicrobial Susceptibility Testing” Informational Supplement M100-S19.

PII: S0196-4399(09)00012-9

doi: 10.1016/j.clinmicnews.2009.02.005

Clinical Microbiology Newsletter
Volume 31, Issue 6 , Pages 41-44 , 15 March 2009

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