Ljungan Virus: an Emerging Zoonosis?

Abstract

Ljungan virus (LV), a picornavirus, was discovered in the Swedish vole population after six clustered deaths from myocarditis were noted in orienteers between 1989 and 1992. Four of five sera from the orienteer patients had detectable antibodies against one of the LV isolates. Researchers tracked data about the population density of Swedish voles carrying LV and compared them to various disease incidences in humans in northern Sweden. Both animal and human data support the possibility that LV causes or contributes to diabetes, fetal death, fetal malformations, and sudden infant death syndrome. Current research has raised the question of the importance of this newly recognized zoonotic pathogen within rodent vectors. Evidence indicates that it would be prudent to consider LV infection in clinical practice, and LV will no doubt be the subject of upcoming intensive research.