Clinical Microbiology Newsletter
Volume 31, Issue 23 , Pages 177-182 , 1 December 2009

Ljungan Virus: an Emerging Zoonosis?

  • Anna Greene McDonald, M.D.

      Affiliations

    • Corresponding Author InformationMailing address: Anna Greene McDonald, M.D., Massachusetts General Hospital, 55 Fruit St., WRN 219, Boston, MA 02114. Tel.: 617-724-1408. Fax. 617-726-7474

References 

  1. Wesslen L , et al.   Myocarditis caused by Chlamydia pneumoniae (TWAR) and sudden unexpected death in a Swedish elite orienteer . Lancet . 1992;340:427–428
  2. Niklasson B , Hornfeldt B , Lundman B . Could myocarditis, insulin-dependent diabetes mellitus, and Guillain-Barre syndrome be caused by one or more infectious agents carried by rodents? . Emerg. Infect. Dis. . 1998;4:187–193
  3. Niklasson B , et al.   A new picornavirus isolated from bank voles (Clethrionomys glareolus) . Virology . 1999;255:86–93
  4. Johansson ES , et al.   Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype . J. Gen. Virol. . 2003;84:837–844
  5. Tolf C , et al.   Molecular characterization of a novel Ljungan virus (Parechovirus; Picornaviridae) reveals a fourth genotype and indicates ancestral recombination . J. Gen. Virol. . 2009;90:843–853
  6. Stanway G , Joki-Korpela P , Hyypia T . Human parechoviruses — biology and clinical significance . Rev. Med. Virol. . 2000;10:57–69
  7. Johansson S , et al.   Molecular analysis of three Ljungan virus isolates reveals a new, close-to-root lineage of the with a cluster of two unrelated 2A proteins . J. Virol. . 2002;76:8920–8930
  8. Peng H , Hagopian W . Environmental factors in the development of Type 1 diabetes . Rev. Endocr. Metab. Disord. . 2006;7:149–162
  9. Wucherpfennig KW . Mechanisms for the induction of autoimmunity by infectious agents . J. Clin. Investig. . 2001;108:1097–1104
  10. Niklasson B , et al.   Type 1 diabetes in Swedish bank voles (Clethrionomys glareolus): signs of disease in both colonized and wild cyclic populations at peak density . Ann. N.Y. Acad. Sci. . 2003;1005:170–175
  11. Niklasson B , et al.   Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus . Int. J. Exp. Diabesity Res. . 2003;4:35–44
  12. Notkins AL , Lernmark A . Autoimmune type 1 diabetes: resolved and unresolved issues . J. Clin. Investig. . 2001;108:1247–1252
  13. Blixt M , Niklasson B , Sandler S . Characterization of beta-cell function of pancreatic islets isolated from bank voles developing glucose intolerance/diabetes: an animal model showing features of both type 1 and type 2 diabetes mellitus, and a possible role of the Ljungan virus . Gen. Comp. Endocrinol. . 2007;154:41–47
  14. Utsugi T , et al.   A new animal model of non-insulin-dependent diabetes mellitus induced by the NDK25 variant of encephalomyocarditis virus . Diabetes Res. . 1992;20:109–119
  15. Jun HS , Yoon JW . The role of viruses in type I diabetes: two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals . Diabetologia . 2001;44:271–285
  16. Naik RG , Palmer JP . Latent autoimmune diabetes in adults (LADA) . Rev. Endocr. Metab. Disord. . 2003;4:233–241
  17. Niklasson B , et al.   Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model . Diabetologia . 2006;49:2192–2199
  18. Phillips DI , Jones A , Goulden PA . Birth weight, stress, and the metabolic syndrome in adult life . Ann. N.Y. Acad. Sci. . 2006;1083:28–36
  19. Silver RM , et al.   Work-up of stillbirth: a review of the evidence . Am. J. Obstet. Gynecol. . 2007;196:433–444
  20. Samsioe A , et al.   Intrauterine death, fetal malformation, and delayed pregnancy in Ljungan virus-infected mice . Birth Defects Res. B. . 2006;77:251–256
  21. Samsioe A , et al.   Fetal death persists through recurrent pregnancies in mice following Ljungan virus infection . Birth Defects Res. B. . 2008;83:507–510
  22. Niklasson B , et al.   Association of zoonotic Ljungan virus with intrauterine fetal deaths . Birth Defects Res. A. . 2007;79:488–493
  23. Botten J , et al.   Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus) . Proc. Natl. Acad. Sci. USA . 2000;97:10578–10583
  24. Niklasson B , et al.   Sudden infant death syndrome and Ljungan virus . Forensic Sci. Med. Pathol. . 2009;
  25. Gilbert-Barness E . Potter's pathology of the fetus, infant, and child . Philadelphia, PA: Mosby Elsevier; 2007;
  26. Bale JF . Congenital infections . Neurol. Clin. . 2002;20:1039–1060 vii.
  27. Niklasson B , et al.   Zoonotic Ljungan virus associated with central nervous system malformations in terminated pregnancy . Birth Defects Res. A. . 2009;85:542–545
  28. Sullivan FM , Barlow SM . Review of risk factors for sudden infant death syndrome . Paediatr. Perinat. Epidemiol. . 2001;15:144–200
  29. Kinney HC , Thach BT . The sudden infant death syndrome . N. Engl. J. Med. . 2009;361:795–805
  30. Filiano JJ , Kinney HC . A perspective on neuropathologic findings in victims of the sudden infant death syndrome: the triple-risk model . Biol. Neonate . 1994;65:194–197
  31. Weese-Mayer DE , et al.   Sudden Infant Death Syndrome: review of implicated genetic factors . Am. J. Med. Genet. A . 2007;143A:771–788
  32. Blackwell CC , et al.   Ethnicity, infection and sudden infant death syndrome . FEMS Immunol. Med. Microbiol. . 2004;42:53–65
  33. Naeye RL . Brain-stem and adrenal abnormalities in the sudden-infant-death syndrome . Am. J. Clin. Pathol. . 1976;66:526–530
  34. Kinney HC , Filiano JJ , White WF . Medullary serotonergic network deficiency in the sudden infant death syndrome: review of a 15-year study of a single dataset . J. Neuropathol. Exp. Neurol. . 2001;60:228–247
  35. Nelson KE , et al.   The sudden infant death syndrome and epidemic viral disease . Am. J. Epidemiol. . 1975;101:423–430
  36. Raza MW , Blackwell CC . Sudden infant death syndrome, virus infections and cytokines . FEMS Immunol. Med. Microbiol. . 1999;25:85–96
  37. Nix WA , et al.   Detection of all known parechoviruses by real-time PCR . J. Clin. Microbiol. . 2008;46:2519–2524
  38. Ekstrom JO , et al.   Physicochemical properties of the Ljungan virus prototype virion in different environments: inactivated by heat but resistant to acidic pH, detergents and non-physiological environments such as Virkon-containing solutions . Microbiol. Immunol. . 2007;51:841–850

PII: S0196-4399(09)00053-1

doi: 10.1016/j.clinmicnews.2009.11.001

Clinical Microbiology Newsletter
Volume 31, Issue 23 , Pages 177-182 , 1 December 2009

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