Clinical Microbiology Newsletter
Volume 32, Issue 2 , Pages 9-15 , 15 January 2010

The Best Practices for Screening, Monitoring, and Diagnosis of Cytomegalovirus Disease, Part II

  • Tiziana Lazzarotto, Ph.D. (Head of the Laboratory of Virology, Operative Unit of Clinical Microbiology)

      Affiliations

    • Corresponding Author InformationMailing address: T. Lazzarotto, Ph.D., U.O. Microbiologia, Policlinico S. Orsola-Malpighi, Via Massarenti n. 9, 40138 Bologna, Italy. Tel.: +39.051.636.3360. Fax: +39.051.307397

References 

  1. Kenneson A , Cannon MJ . Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection . Rev. Med. Virol. . 2007;17:253–276
  2. Boppana S , et al.   Symptomatic congenital cytomegalovirus infection: neonatal morbidity and mortality . Pediatr. Infect. Dis. . 1992;11:93–99
  3. Fowler KB , et al.   The outcome of congenital cytomegalovirus in relation to maternal antibody status . N. Engl. J. Med. . 1992;326:663–667
  4. Bodeus M , et al.   Increased risk of cytomegalovirus transmission in utero during late gestation . Obstet. Gynecol. . 1999;93:658–660
  5. Pass RF , et al.   Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome . J. Clin. Virol. . 2006;35:216–220
  6. Revello MG , Gerna G . Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant . Clin. Microbiol. Rev. . 2002;15:680–715
  7. Dahle AJ , et al.   Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus . J. Am. Acad. Audiol. . 2000;11:283–290
  8. Gabrielli L , et al.   Histological findings in foetuses congenitally infected by cytomegalovirus . J. Clin. Virol. . 2009;46(Suppl. 4):S16–S21
  9. Coll O , et al.   Guidelines on CMV congenital infection . J. Perinat. Med. . 2009;37:433–445
  10. Adler SP , et al.   Prevention of child-to-mother transmission of cytomegalovirus among pregnant women . J. Pediatr. . 2004;145:485–491
  11. Lazzarotto T , et al.   New advances in the diagnosis of congenital cytomegalo virus infection . J. Clin. Virol. . 2008;41:192–197
  12. Macé M , et al.   A serological testing algorithm for the diagnosis of primary CMV infection in pregnant women . Prenat. Diagn. . 2004;24:861–863
  13. Lazzarotto T , et al.   Maternal IgG avidity and IgM detected by blot as diagnostic tools to identify pregnant women at risk of transmitting cytomegalovirus . Viral Immunol. . 2000;13:137–141
  14. Lilleri D , et al.   Development of human cytomegalovirus-specific T cell immunity during primary infection of pregnant women and its correlation with virus transmission to the fetus . J. Infect. Dis. . 2007;195:1062–1070
  15. Guerra B , et al.   Impact of diagnostic and confirmatory tests and prenatal counseling on the rate of pregnancy termination among women with positive cytomegalovirus immunoglobulin M antibody titers . Am. J. Obstet. Gynecol. . 2007;196:221.e1–221.e6
  16. Benoist G , et al.   The prognostic value of ultrasound abnormalities and biological parameters in blood of fetuses infected with cytomegalovirus . Br. J. Obstet. Gynecol. . 2008;115:823–829
  17. Nanal R , et al.   A classification of pregnancy losses after invasive prenatal diagnostic procedures: an approach to allow comparison of units with a different case mix . Prenat. Diagn. . 2003;23:488–492
  18. Enders G , et al.   Prenatal diagnosis of congenital cytomegalovirus infection in 189 pregnancies with known outcome . Prenat. Diagn. . 2001;21:362–377
  19. Lazzarotto, T. et al. 2009. Prenatal diagnosis of congenital cytomegalovirus (CMV) infection and outcome in 598 pregnant women undergoing a primary CMV infection. OR 10.2. In Abstracts of the 12th International CMV/BetaHerpesvirus Workshop, 10-14 May 2009, Boston, MA.
  20. Lanari M , et al.   Neonatal cytomegalovirus blood load and risk of sequele in symptomatic and asymptomatic congenitally infected newborns . Pediatrics . 2006;117:e76–e83
  21. Barbi M , et al.   Diagnosis of congenital CMV infection via dried blood spots . Rev. Med. Virol. . 2006;16:385–392
  22. Boppana S . Newborn CMV screening: NIDCD CHIMES Study. Congenital Cytomegalovirus Conference 2008, Atlanta, GA, 5-7 November 2008 . http://www.congenitalcmv.org.htm
  23. Rosenthal LS , et al.   Cytomegalovirus shedding and delayed sensorineural hearing loss: results from longitudinal follow-up of children with congenital infection . Pediatr. Infect. Dis. J. . 2009;28:515–520
  24. Nigro G , et al.   Passive immunization during pregnancy for congenital cytomegalovirus infection . N. Engl. J. Med. . 2005;353:1350–1362
  25. Jacquemard F , et al.   Maternal administration of valaciclovir in symptomatic intrauterine cytomegalovirus infection . Br. J. Obstet. Gynecol. . 2007;114:1113–1121
  26. Kimberlin DW , et al.   Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial . J. Pediatr. . 2003;143:16–25
  27. Kimberlin DW , et al.   Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease . J. Infect. Dis. . 2008;197:836–845
  28. Pass RF , et al.   Vaccine prevention of maternal cytomegalovirus infection . N. Engl. J. Med. . 2009;360:1191–1199

 Editor's Note: Part I of this article was published in the January 1, 2010 issue of CMN (Vol. 32, No. 1).

PII: S0196-4399(09)00062-2

doi: 10.1016/j.clinmicnews.2009.12.004

Clinical Microbiology Newsletter
Volume 32, Issue 2 , Pages 9-15 , 15 January 2010

Article Tools

* Image Usage & Resolution