Clinical Microbiology Newsletter
Volume 32, Issue 5 , Pages 33-37 , 1 March 2010

Code Sepsis: Rapid Methods To Diagnose Sepsis and Detect Hematopathogens: Part I: The Impact and Attributes of Sepsis

  • Donna M. Wolk, MHA, Ph.D., D(ABMM)

      Affiliations

    • Corresponding Author InformationMailing address: Donna M. Wolk, MHA, Ph.D., D(ABMM), Assistant Professor, Department of Pathology, University of Arizona, 1501 N. Campbell Ave., P.O. Box 245059, Tucson, AZ 85724-5059. Tel.: 520-626-3676. Fax:520-694-7329
  • ,
  • Albert B. Fiorello, M.D.

References 

  1. Esper A , Martin GS . Is severe sepsis increasing in incidence AND severity? . Crit. Care Med. . 2007;35:1414–1415
  2. Danai P , Martin GS . Epidemiology of sepsis: recent advances . Curr. Infect. Dis. Rep. . 2005;7:329–334
  3. Cribbs SK , Martin GS . Expanding the global epidemiology of sepsis . Crit. Care Med. . 2007;35:2646–2648
  4. Angus DC , et al.   Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care . Crit. Care Med. . 2001;29:1303–1310
  5. Balk RA . Pathogenesis and management of multiple organ dysfunction or failure in severe sepsis and septic shock . Crit. Care Clin. . 2000;16:337–352 vii.
  6. Balk RA . Severe sepsis and septic shock. Definitions, epidemiology, and clinical manifestations . Crit. Care Clin. . 2000;16:179–192
  7. Sands KE , et al.   Epidemiology of sepsis syndrome in 8 academic medical centers . JAMA . 1997;278:234–240
  8. Angus DC , et al.   Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care . Crit. Care Med. . 2001;29:1303–1310
  9. Burchardi H , Schneider H . Economic aspects of severe sepsis: a review of intensive care unit costs, cost of illness and cost effectiveness of therapy . Pharmacoeconomics . 2004;22:793–813
  10. Wenzel RP , Edmond MB . Severe sepsis — national estimates . Crit. Care Med. . 2001;29:1472–1474
  11. Wang HE , et al.   National estimates of severe sepsis in United States emergency departments . Crit. Care Med. . 2007;35:1928–1936
  12. Watson RS , et al.   The epidemiology of severe sepsis in children in the United States . Am. J. Respir. Crit. Care Med. . 2003;167:695–701
  13. Biswal S , et al.   Drug utilization pattern in the intensive care unit of a tertiary care hospital . J. Clin. Pharmacol. . 2006;46:945–951
  14. Laupland KB , et al.   Cost of intensive care unit-acquired bloodstream infections . J. Hosp. Infect. . 2006;63:124–132
  15. Mokart D , et al.   Early postoperative compensatory anti-inflammatory response syndrome is associated with septic complications after major surgical trauma in patients with cancer . Br. J. Surg. . 2002;89:1450–1456
  16. Mokart D , et al.   Predictive perioperative factors for developing severe sepsis after major surgery . Br. J. Anaesth. . 2005;95:776–781
  17. Okabayashi T , Hanazaki K . Overwhelming postsplenectomy infection syndrome in adults — a clinically preventable disease . World J. Gastroenterol. . 2008;14:176–179
  18. Spelman D , et al.   Guidelines for the prevention of sepsis in asplenic and hyposplenic patients . Intern. Med. J. . 2008;38:349–356
  19. Olsen I . Update on bacteraemia related to dental procedures . Transfus. Apher. Sci. . 2008;39:173–178
  20. Gurusamy KS , Kumar Y , Davidson BR . Methods of preventing bacterial sepsis and wound complications for liver transplantation . Cochrane Database Syst. Rev. . 2008;4: CD006660.
  21. Williams MD , et al.   Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care . Crit. Care . 2004;8:R291–R298
  22. Rangel-Frausto MS , et al.   The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study . JAMA . 1995;273:117–123
  23. Dellinger RP , et al.   Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008 . Intensive Care Med. . 2008;34:17–60
  24. Nguyen HB , et al.   Early lactate clearance is associated with improved outcome in severe sepsis and septic shock . Crit. Care Med. . 2004;32:1637–1642
  25. Rivers E , et al.   Early goal-directed therapy in the treatment of severe sepsis and septic shock . N. Engl. J. Med. . 2001;345:1368–1377
  26. Kumar A , et al.   The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: association with serum lactate and inflammatory cytokine levels . J. Infect. Dis. . 2006;193:251–258
  27. Sharma S , Kumar A . Antimicrobial management of sepsis and septic shock . Clin. Chest Med. . 2008;29:677–687 ix.
  28. Hunfeld KP , et al.   Molecular biological detection of pathogens in patients with sepsis. Potentials, limitations and perspectives . Anaesthetist . 2008;57:326–337
  29. Knaus WA . Mortality risk prediction in sepsis . Crit. Care Med. . 1995;23:1793–1794
  30. Osborn TM , Nguyen HB , Rivers EP . Emergency medicine and the Surviving Sepsis Campaign: an international approach to managing severe sepsis and septic shock . Ann. Emerg. Med. . 2005;46:228–231
  31. Rivers E , et al.   Early goal-directed therapy in the treatment of severe sepsis and septic shock . N. Engl. J. Med. . 2001;345:1368–1377

 Editor's Note: Part II of this article will appear in the March 15, 2010 issue of CMN, Volume 32, Number 6.

PII: S0196-4399(10)00007-3

doi: 10.1016/j.clinmicnews.2010.02.001

Clinical Microbiology Newsletter
Volume 32, Issue 5 , Pages 33-37 , 1 March 2010